04 Nov Report Of Meeting With MHRA On Regulation of Cannabidiol (CBD).
Yesterday, 3rd November 2016, six delegates from the UK Cannabis Trade Association (UKCTA) met with Medicines and Health Products Regulatory Agency (MHRA) representatives at the agency’s headquarters in Victoria.
We were courteously received. The meeting was cordial, productive and enabled both sides to clarify their positions and better understand each other’s perspective.
In summary, in my opinion, there is no immediate threat to to CBD consumers or businesses. The MHRA has now extended until 31 December 2016 the date by which businesses should voluntarily comply with its opinion, either by withdrawing existing products from the market, or by complying with necessary regulation. Thereafter, the next step would be to begin the process of statutory enforcement. This would take a matter of some months and I believe, even were this to be started, we are looking at more than a year before any impact would be felt. More importantly, based on the meeting, I think the outcome is likely to be that we can negotiate a form of regulation that will work for everyone.
The MHRA team was led by Gerald Heddell, Director of Inspection, Enforcement and Standards. Also present were regulatory advisors David Olszowska and Chris Groutides; Dr Chris Jones, Manager of the Medicines Borderline Section; Greg Markey, Senior Medical Assessor and Malcolm Evans, Head of Patient, Public and Stakeholder Engagement. Mr Heddell opened the meeting by thanking us for bringing to the agency’s attention just how many people are using CBD, some for quite serious medical conditions.
The MHRA set out its reasons for its opinion that products containing CBD used for medical purposes are medicines. Greg Markey explained the mechanisms of action and pharmacology that had been considered and Dr Jones explained that the Borderline Section existed to deal specifically with products where it was difficult to determine whether they should be regarded as medicines or food supplements. The example was offered of vitamin C where if it was being used to treat scurvy then it was clearly a medicine, whereas if it was used to supplement a normal diet it could be regarded as a food supplement. We were able to explain that all so-called CBD products on the market, with the exception of crystals, are actually whole plant extracts from low-THC cannabis, usually industrial hemp. We pointed out that the growth in the CBD market had been driven by people seeking the therapeutic benefits of medicinal cannabis which until now had been denied by the British government.
The nub of the issue is really the nature of the condition for which CBD is used. The MHRA has already issued orphan designations for CBD for Dravet Syndrome, graft versus host disease and perinatal asphyxia. Orphan designations are granted where the benefit of a medicine can be recognised even though necessary regulatory processes have not yet been completed. It is important to understand that this is what has guided the MHRA’s opinion, viewing CBD as a medicine for very serious conditions.
We discussed a range of options whereby, at the lowest level, CBD products could continue to be marketed as a food supplement. For minor conditions, not requiring medical supervision, it may be possible to obtain a Traditional Herbal Registration (THR) at a cost of a few hundred pounds. A third option is a ‘Specials’ exemption where a doctor or prescriber has specified and taken responsibility for an unlicensed medicine for a particular patient. Finally, the highest level is a Marketing Authorisation (MA) where the costs including fees and clinical trials are probably a minimum of £250,000.
It is our view that CBD products should be regulated at all these different levels dependent on the purpose for which they are used and the concentration at which CBD is present. We have agreed that we will write formally setting out these proposals and the MHRA will respond accordingly.
The UKCTA and a number of individual companies have now obtained legal advice including counsel’s opinion. We have shared this with the MHRA and formal solicitors letters have already been served. In essence, the advice is that the MHRA has failed to comply with its own guidelines and requirements in issuing its opinion to CBD suppliers and that any requirement to comply with regulations would have to be addressed on an individual, product by product basis.
So, all in all, we believe the meeting was a success. We demonstrated that the new trade association is to be taken seriously and that we will work constructively with the agency. There was visible surprise at the level of professionalism we presented, particularly with the legal advice we had obtained. I believe we convinced the MHRA that we could establish a set of rules, guidelines and standards that would enable the industry to comply with its requirements.
The CBD market in the UK is presently worth several million pounds a year. If it is to continue to grow, provide safe, effective products for consumers and patients and job security for its workers, then we need to establish UKCTA so that it effectively represents the whole industry. We need to show that we are responsible, we care, we are professionals and we are ready to put our collective head above the parapet as a legal, ethical and regulated industry.
Rob AtkinsonPosted at 11:41h, 06 November
Whilst applauding any effort to curtail the decision of the MHRA to impose their will, my question is who exactly empowered
(UKCTA) to speak one everyone’s behalf?? who are they – who elected them to speak on our behalf – are these some the 18 companies who have been written to thereby the cause of the MHRA’s decision to sanction sales??
Peter ReynoldsPosted at 14:07h, 06 November
UKCTA is an initiative that a number of people in the CBD business started in early September. You can see some of the key members in the photograph above. In all, about 25 people are involved, most of whom represent a business which either markets CBD products or grows cannabis under a Home Office licence. We are in the process of formalising the legal status of the group and we will be announcing a membership structure very shortly.
Anyone who has a legitimate interest in the cannabis trade in the UK is welcome to join us. Aside from the immediate issue of representing the industry to the MHRA, one of our first aims is to publish a code of conduct detailing ethical and quality standards.
Rob AtkinsonPosted at 13:40h, 07 November
Hi Peter, Thank you for your response, but to be honest I am no further enlightened by it?
Maybe you could read the question again and reply accordingly.
My questions are who exactly empowered (UKCTA) to speak one
Who are (UKCTA) – Who elected them to speak on our
Are these some the 18 companies who have been written to
thereby the cause of the MHRA’s decision to sanction sales??
Peter ReynoldsPosted at 16:50h, 08 November
I don’t know how I can make it any more clear! UKCTA took the initiative itself. Yes, some of our members received letters from the MHRA – not about sanctioning sales but seeking to stop them.
Leebe KingPosted at 07:12h, 12 November
Hi Peter can you please tell me if CBD will still be available to buy in the uk? If I’m reading the above correctly this means consumers can still buy it for atleast the next year until statutory enforcement? Thanks
Peter ReynoldsPosted at 16:59h, 12 November